We’ve recently added to our fleet of advanced analytical instrumentation housed in UConn PMF! Installation updates on several new technologies can be found listed below.
Bruker timsTOF HT & Thermo Scientific Vanquish Flex & Neo UPLCs: In early 2022, UConn PMF was granted funds from the UConn OVPR to acquire a brand new state-of-the-art mass spectrometer that will provide substantially improved analytical capabilities for both proteomics and metabolomics applications! These funds allowed us to purchase a brand new Bruker timsTOF HT plus 2 new UPLCs (nanoflow + analytical flow). We’ve completed installation of this new instrumentation in Spring 2023 and are currently in the midst of method optimization studies prior to opening the instrument up for new user experiments. Stay tuned for announcements about new functionalities, a summary of instrument performance, and user access details!
Biognosys Spectronaut v17 DIA analysis software: We’ve recently purchased a perpetual license for the Spectronaut software program, which allows us to expand our acquisition method options to include Data-Independent Acquisition (DIA) MS for deeper proteome coverage and greater quantitative reproducibility across proteomic experiments. We are also working on a post-Spectronaut statistical analysis platform for UConn PMF users in partnership with UConn Statistical Consulting Services (https://statsconsulting.uconn.edu/). We will provide more information on this new tool very soon!
Waters Corporation Hydrogen-Deuterium Exchange (HDX) capabilities featuring Trajan Scientific Automation: In late 2022 we were awarded a College of Liberal Arts (CLAS) Shared Equipment Award to purchase HDX hardware to install on our existing Waters Synapt G2Si TOF mass spectrometer. We have recently installed the Waters UPLC pumps and are awaiting delivery of the Trajan robotics system to allow fully automated HDX-MS analysis for the first time at UConn! We anticipate that this new technology will be available for users beginning in late Summer 2023.
Stay tuned for more information and announcements regarding upcoming seminars, during which we will formally introduce our new analysis options!